
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, identified in 2015 as one of a small class of mitochondrial-derived peptides. Research has examined its action through the folate-methionine cycle and AMPK activation, and its movement into the nucleus under metabolic stress. Interventional evidence is preclinical, with no completed human trials.
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For laboratory research use only. Not for human consumption.